14^th International Conference on Pulmonary & Respiratory Medicine August 21-22, 2023 Dubai, UAE

Biography:

Hieba Gamal Ezzelregal is an assisstant professor of chest dieases Ain Shams University. Worked in the academic and clinical field of ain shams university hospitals, graduated and took M.D degree from Ain Shams University. recently enjoyed and intersted in scientific writing and publishing.

Abstract:

Statement of the Problem: investigating the role that changes in the diaphragmatic shape and movement play in the development of dyspnea in patients with pleural effusion. As Dyspnea that is caused by pleural effusion and affects patients’ quality of life may not be resolved after lung expansion following pleural tapping.  Thirty patients with pleural effusions and dyspnea were evaluated before and at 24 h after therapeutic thoracentesis. The primary outcomes are to investigate changes in diaphragmatic shape and movement before and after thoracentesis by chest ultrasound to evaluate factors causing effusion-related dyspnoea, while the secondary outcomes are firstly to investigate the effect of pleural effusion on the cardiorespiratory, functional, and diaphragmatic variables in causing dyspnea and secondly to detect the percentages and demographics of patients who experience post-drainage dyspnea improvement.

Biography:

Zohre Eftekhari works at Pasteur Institute of Iran, Iran

Abstract:

Background:Exposure to Cadmium (Cd) primarily occurs through the ingestion of contaminated food and water and, through inhalation and smoking. Magnesium plays an essential role in the synthesis and metabolism of vitamin D. Aim: So there is a possible interaction between magnesium and vitamin D, which affect each other’s condition in the lung clinical indicators of Cadmium toxicity. Material and Methods: 50 female Wistar rats were divided into 5 groups as follow: Control, Cd, Cd +vitamin D, Cd +Mg, and Cd +vitamin D +Mg. Induction of Cd poisoning model was done using the intraperitoneal injection of Cd at a dose of 2 mg/kg for 28 days and subsequently vitamin D and Mg were administrated at the doses of 100 and 1 mg/kg, respectively. The rat’s body weight, toxicity index, hematological parameters, and hepatic function were evaluated. VEGF and BMP-4 protein expression and liver enzymes level were also determined using western blot analysis and commercial biochemical kits. Isolated lungs histopathological examination was performed as well as. Following Cd exposure, significant increase in the levels of liver enzymes, toxicity index, VEGF and BMP-4 expression was observed. 

Biography:

Abderrahmane Errami, Ph.D. in Immunogenetics and Molecular Pathology, from the Faculty of Medicine and Pharmacy in Casablanca and a member of the European Society for Primary Immunodeficiency (ESID), African Society for Primary Immunodeficiency (ASID) and Arabic Society for Primary Immunodeficiency.As soon as he joined the research team at Casablanca Children’s Hospital, the Reference Center for Primary Immunodeficiency in Morocco, he took charge of the National Registry for Primary Immunodeficiency. He has written several articles in English, French, and Arabic and has given lectures at national and international meetings. He was also part of the organizing committee for several scientific events in person or online.

Abstract:

Tuberculosis, caused by Mycobacterium tuberculosis (M.tb), has caused more than a billion deaths over the last 200 years, more than malaria, smallpox, influenza, AIDS, cholera, and plague combined. There was a remarkable interindividual variability in the outcome of exposure to M.tb and the course of infections. Although genome-wide association studies have identified loci associated with host predisposition or resistance to tuberculosis, their results were not consistent or reproducible. The first molecular evidence of a monogenic predisposition to mycobacteria came from the study of Mendelian susceptibility to mycobacterial disease (MSMD), which confers a selective susceptibility to weakly virulent mycobacteria, such as BCG vaccine and various environmental mycobacteria, in otherwise healthy individuals. Patients are also vulnerable to M.tb and about half of them develop non-typhoidal salmonellosis. In specific genetic disorders, patients also suffer from chronic mucocutaneous candidiasis (CMC), viral and/or, more rarely, parasitic infections. To date, 35 genetic disorders caused by mutation of 19 genes (IFNGR1, IFNGR2, IFNG, IL12RB1, IL12RB2, IL23R, IL12B, ISG15, USP18, ZNFX1, TBX21, STAT1, TYK2, IRF8, CYBB, JAK1, RORC, NEMO and SPPL2A) have been shown to cause MSMD. Almost all genetic etiologies of MSMD impair or abolish IFN-γ production or the response to this cytokine or both. The human IFN-γ level is a quantitative trait that defines the outcome of mycobacterial infection. The study of MSMD has greatly improved our understanding of the molecular mechanism of mycobacterial infections in humans and allowed the development of new diagnostic and therapeutic approaches to improve care and prognosis. For example, MSMD patients with impaired production of IFN-γ may benefit from injections of human recombinant IFN-γ, while for patients with abolished response to IFN-γ, hematopoietic stem cell transplantation (HSCT) and promising gene therapy are the only current therapeutic options. These discoveries also bridge the gap between simple Mendelian inheritance and complex human genetics.

Biography:

Dr. Alireza Derakhshan is an Iranian physician and academic with a PhD in Traditional Persian Medicine. He is currently an assistant professor in Mashhad University of Medical Sciences and a board member of the Iranian Traditional Medicine Association. He has supervised a number of Ph.D., residency, and M.D. theses, covering topics such as the effects of traditional Persian medicine herbal therapies on asthma, allergic rhinitis, COPD, chronic urticaria, psoriasis, impaired intestinal permeability, and etc. Additionally, he has authored or co-authored several research articles and has presented his research at several conferences. Dr. Derakhshan has more than 4 years of medical experience as an integrative physician and has completed several courses in acupuncture, teaching skills, electronic learning, and apitherapy.

Abstract:

Biography:

I am Ayda Esmaeili , I am pharm-D and have Board certification of clinical pharmacy from Tehran university. I  do research, teach as an assistant professor and clinical practice as a clinical pharmacist in both hospital and education institutions. I conducted varies clinical trials in internal medicine disease including endocrinology, pulmonology and etc..

Abstract:

Objective: Chronic obstructive pulmonary disease (COPD) is associated with many health complications, including pulmonary hypertension (PH). Although oral calcium channel blockers have shown promising results in managing COPD-induced PH, significant systemic side effects may limit their use in this population. Administering verapamil through nebulization can be an alternative approach. We aim to assess the possible therapeutic effects of verapamil inhalation in out-patients with pulmonary hypertension (PH) secondary to COPD. Methods: A double-blind, randomized placebo-controlled clinical trial was conducted. Patients with PH were randomly assigned to two groups of 15 participants. The intervention group received a short-term single dose of 10 mg nebulized verapamil (4 ampoules of 2.5 mg/ml verapamil solutions). The control group received nebulized distilled water as a placebo in addition to their standard treatment throughout the study. Results: Systolic pulmonary artery pressure (sPAP) did not improve as a primary outcome significantly in patients receiving nebulized verapamil compared with those on placebo (p = 0.89). Spirometry results showed a significant improvement in FVC in the intervention group from 1.72 ± 0.63 to 1.85 ± 0.58 L (p = 0.00), and FEV1/FVC ratio decreased significantly after verapamil administration (p = 0.027).

Biography:

Prof. Dr. Anil Batta is presently professor & Head with senior consultant in Govt. Medical College, Amritsar. He did his M.B.B.S. and M.D. in Medical Biochemistry from Govt. Medical College, Patiala in 1984 and 1991, respectively. His research interest is mainly in clinical application especially cancer and drug de-addiction. He has supervised more than 25 M.D., M.Sc. and Doctorate researches and published more than 130 international research papers. He is the chief editor of America’s Journal of Biochemistry

Abstract:

Mechanical ventilation is a life-support system used to maintain adequate lung function in patients who are critically ill or undergoing general anesthesia. The benefits and harms of mechanical ventilation depend not only on the operator’s setting of the machine (input), but also on their interpretation of ventilator-derived parameters (outputs), which should guide ventilator strategies. Once the inputs—tidal volume (VT), positive end-expiratory pressure (PEEP), respiratory rate (RR), and inspiratory airflow (V’)—have been adjusted, the following outputs should be measured: intrinsic PEEP, peak (Ppeak) and plateau (Pplat) pressures, driving pressure (ΔP), transpulmonary pressure (PL), mechanical energy, mechanical power, and intensity. During assisted mechanical ventilation, in addition to these parameters, the pressure generated 100 ms after onset of inspiratory effort (P0.1) and the pressure-time product per minute (PTP/min) should also be evaluated. The aforementioned parameters should be seen as a set of outputs, all of which need to be strictly monitored at bedside in order to develop a personalized, case-by-case approach to mechanical ventilation. Additionally, more clinical research to evaluate the safe thresholds of each parameter in injured and uninjured lungs is required.

Biography:

Dr. Nada Mohsen Lecturer of Radiodiagnosis and interventional radiology, having great interest in the development of thoracic interventional procedure, starting her career in the National cancer since 2012. She has been incorporated in this study since 2018. Currently we are implicating modifications to lung biopsy procedures aiming to reduce complications and improve diagnostic accuracy to provide adequate pathological samples to help tailor personalized treatment plans for pulmonary cancer cases.

Abstract:

Our study aims to assess the efficiency of post lung biopsy Gelfoam slurry embolization in decreasing the risk of post procedural complications in the form of pneumothorax, hospital admission and need for further intervention.This is prospective randomized control study where 70 CT guided biopsies performed with tract embolization were compared to 68 controls. After the biopsy, patients were kept under 4-6 hours observation. Pre- procedural, procedural risk factors were recorded.  Complications recorded as pneumothorax, pneumothorax requiring chest tube insertion. Hemorrhagic complications in general were divided as (hemothorax, hemoptysis, pulmonary parenchymal hemorrhage). The total rate for hospital admission were recorded.