Zohre Eftekhari
Pasteur Institute of Iran, Iran
Title: Vitamin D and Mg Attenuate Cadmium-Induced Lung Impairment in Rats
Biography
Biography: Zohre Eftekhari
Abstract
Background:Exposure to Cadmium (Cd) primarily occurs through the ingestion of contaminated food and water and, through inhalation and smoking. Magnesium plays an essential role in the synthesis and metabolism of vitamin D. Aim: So there is a possible interaction between magnesium and vitamin D, which affect each other’s condition in the lung clinical indicators of Cadmium toxicity. Material and Methods: 50 female Wistar rats were divided into 5 groups as follow: Control, Cd, Cd +vitamin D, Cd +Mg, and Cd +vitamin D +Mg. Induction of Cd poisoning model was done using the intraperitoneal injection of Cd at a dose of 2 mg/kg for 28 days and subsequently vitamin D and Mg were administrated at the doses of 100 and 1 mg/kg, respectively. The rat’s body weight, toxicity index, hematological parameters, and hepatic function were evaluated. VEGF and BMP-4 protein expression and liver enzymes level were also determined using western blot analysis and commercial biochemical kits. Isolated lungs histopathological examination was performed as well as. Following Cd exposure, significant increase in the levels of liver enzymes, toxicity index, VEGF and BMP-4 expression was observed.